During Total Drama World Tour, Chris rented out Camp Wawanakwa to a toxic waste company, which used it as their main dump. By the time Chris bought it back for the new season, it was filled with biohazardous toxic waste, affecting the island and its inhabitants; making it more dangerous for a new generation. The cast of thirteen is divided into two teams and must compete in many deadly, disgusting, and humiliating challenges. One by one, they are eliminated in a manner similar to the original season, but with a twist; when the bottom two is reached, the person whose name is called last is the one who is eliminated, and thus receives the last marshmallow, which is toxic. After the camper is eliminated, they are catapulted off the island in the Hurl of Shame. The last contestant standing is crowned the winner and receives the $1,000,000, as the host is arrested at the end of the season.
Pre-Merge[]
| # | Title | Brief Summary | Airdate | Screenshot |
| 1 | Bigger! Badder! Brutal-er! | This season finally begins, introducing a whole new cast, set at Camp Wawanakwa, which has turned into a bio-hazardous waste dump. The thirteen contestants are divided into two teams, the Toxic Rats and the Mutant Maggots. Two contestants build a close bond, and one contestant manages to annoy her entire team into eliminating her that night. | January 5, 2012 | |
| 2 | Truth or Laser Shark | As the competition narrows down to twelve, the campers must compete in the first part of their challenge; a tell-all trivia game which ends up embarrassing several contestants. Due to the problems in round one, the host makes the second round miserable for both teams. Ironically, a nonathletic camper ends up winning the physical-oriented challenge for his team, sending the other team to the elimination ceremony. In the end, someone becomes too focused on her image and is quickly voted off. | January 12, 2012 | |
| 3 | Ice Ice Baby | The remaining contestants take part in a frigid challenge including climbing a mountain and a snowy capture the flag game. One of the Maggots asserts herself further as team leader, while a Rat continues to ruin his team's chances regardless of other's abilities. Someone gets fearful of his secret being discovered, but it comes through with another victory for his team. Ultimately, through a cruel trick by the evil, a camper is thrown off the island while someone else returns in a fame-desperate move. | January 19, 2012 | |
| 4 | Finders Creepers | The two teams are sent into the the woods on a scavenger hunt, where one camper's alternate personality hooks up with someone else, despite their true self being in love with a different camper. Meanwhile, someone continues to sabotage his team's chances, but fails in the end due to someone else persisting towards a victory. The losing team attends their first elimination ceremony, where someone volunteers for elimination, but ends up on the winning team, while an intern is eliminated again. | January 26, 2012 | |
| 5 | Backstabbers Ahoy! | As one team deals with their newest member, the other is severely divided by one contestant, who shares feelings for two girls at once. When the contestants' most prized possessions start vanishing, one player initially accuses his teammate, but then places the blame on someone else. Although she figured out the true scheme, it is not enough to prevent elimination. | February 2, 2012 | |
| 6 | Runaway Model | As one team suffers dysfunction after a particular gamer feels as if they are lacking in the macho department, the other team shows problems with the over-macho nature of another and a persistent conflict of two others. In the end, a contestant suffering from withdrawal loses the game, but wins the heart of the girl of his dreams. Later, in a shocking surprise twist, the host forces two contestants to switch teams. | February 9, 2012 | |
| 7 | A Mine is a Terrible Thing to Waste | The two teams are sent into an abandoned mine, where one camper takes charge of their team, and someone's disorder gets more out of hand. Someone throws the challenge to save his old team, leading to his elimination. Meanwhile, an old contestant falls in love with a new contestant, and gives her a special reward, which leads to her quitting the competition, and a former intern returning to her former team as her place as a contestant. | February 16, 2012 | |
| 8 | The Treasure Island of Dr. McLean | The teams wake up in the middle of the lake, where a returnee starts mutating due to a toxic exposure, and seeks help from a fellow teammate. Meanwhile, another member tries to help a friend keep his secret under control. Someone is revealed to have found the idol, and asks someone else to keep it a secret. The finder is eliminated, but uses his discovery and his new friend to eliminate a mutant instead. | February 23, 2012 |
Post-Merge[]
| # | Title | Brief Summary | Airdate | Screenshot |
| 9 | Grand Chef Auto | The teams are merged, and the host sends the players on a challenge that someone quickly takes control of. Due to one person's slip-up, someone with a secret is forced under another until he finally stands up to take control and save his crush. Although someone appears to have a come-from-behind victory after being betrayed, the host gives the rewards to the original winner, which allows him to eliminate a cured camper. | March 1, 2012 | |
| 10 | Up, Up & Away in My Pitiful Balloon | It's down to the final five, and when the host places the campers in an aerial-based challenge, three dangerous threats start attempting to outfox each other. However, after an old contestant shows up and steals what almost was hers, the original challenge is changed in order to catch her. In the end, the goal is reclaimed, and a traitorous jock is betrayed by a former alliance member, and finally takes the Hurl of Shame. | March 8, 2012 | |
| 11 | Eat, Puke & Be Wary | The final four are forced to partake in a disgusting cooking challenge, due to the host falling into an antagonist's trap. Two contestants align to get rid of their enemy, while their enemy tries to eliminate a physical threat. The host's substitute hunts the contestants down in the woods, and one contestant becomes tired of being pushed around. Someone steals immunity from someone else, and their enemy, along with his fear, is sent home for good. | March 22, 2012 | |
| 12 | The Enchanted Franken-Forest | The final three face off in a forest full of toxic carnivorous plants. An alliance between two contestants is severely strained by the challenge. When one is in danger, the other finally gives up the challenge in order to save her friendship, allowing someone else to win the challenge and the choice of who to eliminate. Surprisingly, the winner picks the bigger threat to be eliminated, so that he can settle his rivalry with the other for good in the final two. | March 29, 2012 | |
| 13 | Brain vs. Brawn: The Ultimate Showdown | After a long, hard, and painful season, only two contestants remain to battle it out for the million-dollar prize. They are taken to a coliseum to battle it out in the ultimate final challenge. In addition to fighting each other, they must also overcome numerous obstacles during the challenge. In the end, one contestant, wins the challenge, the money, and the season. | April 12, 2012 |
Both Total Drama: Revenge of the Island and Total Drama Island are the highest rated shows on the series.